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Ketamine Assisted Psychotherapy Information Guide



Welcome to Anywhere Clinic Psychiatry. This blog contains important information about Ketamine Assisted Psychotherapy (KAP), as well as  about ketamine itself. If you are wondering if KAP is right for you or a loved one, please read through this carefully to better understand our services and how KAP can be beneficial.


If you decide to move forward with an intake, we will work to answer all of your questions prior to making the decision to start KAP. It is very important to us that you feel welcomed, safe, and respected, and to address any concerns you might have about the process. 


What is Ketamine? 

Ketamine is a synthetic pharmaceutical compound, classified as a dissociative anesthetic. It is one of the most widely used drugs in modern medicine, and is on the World Health Organization’s List of Essential Medicines. It was developed in 1963, FDA approved in 1970, and adopted by many hospitals and medical offices because of its rapid onset, proven safety, and short duration of action. 

Ketamine is most commonly used in surgical settings, including pediatric surgery, due to its excellent safety profile, particularly around breathing/airway management. It has also been utilized successfully in managing acute and chronic pain conditions due to its analgesic properties.


In the last two decades, ketamine has been increasingly clinically applied at subanesthetic doses as an off-label treatment for various chronic treatment resistant mental health conditions, such as depression, alcoholism, substance  dependencies, post-traumatic stress disorder, obsessive compulsive disorder, and other psychiatric diagnoses. 

Non-medical and recreational use of ketamine began in the late 1970s, leading to its cultural reputation as a club/party drug; it was also enthusiastically adopted by the psychedelic community and others who value exploration of altered states. 


How Ketamine Works 

As mentioned, ketamine is classified as a dissociative anesthetic, where “dissociation” means a sense of disconnection between mind and body, and from one’s ordinary reality and usual sense of self. The present understanding of ketamine’s mode of action is as an NMDA antagonist working through the glutamate neurotransmitter system. (This is a different pathway than that of other psychiatric drugs such as the SSRIs, SNRIs, lamotrigine,  antipsychotics, benzodiazepines, etc.) Another hypothesis is that ketamine offers a break from the usual patterns of thought that underlie mood and behavior, thereby creating an opportunity for learning new and healthier patterns of thought.


Dosing Strategies and Route of Administration 


Ketamine can be administered in a variety of ways, including as an intravenous  infusion (IV), intramuscular injection (IM), a subcutaneous injection (SC), intranasally, or sublingually/orally as a dissolving troche or tablet. Routes vary in the onset, bioavailability and duration of active effects for each person. 

Though research has demonstrated an antidepressant response to low doses that are minimally psychoactive or sub-psychedelic, this effect tends to be cumulative, requiring repeated administrations over short periods of time. Some practitioners view the psychedelic and dissociative experiences that occur at higher doses to provide a more robust and longer-lasting outcome. 

Though experiences vary greatly, it is generally thought that lower doses provide empathogen-like (heart-opening) responses, while higher doses create dissociative, psychedelic, out-of-body, ego-dissolving peak responses. 

We use a range of dosing and route of administration (ROA) strategies to tailor a  personalized approach for each client. In our practice, ketamine is administered by either: 

  • Sublingual (oral) dissolving tablets, a lower-dose strategy which may allow for psychotherapy during the treatment, and an easier experience for those who are hesitant about injections

  • Intramuscular injection (IM), given in the shoulder, delivers a highly bioavailable amount of medicine and a rapid onset. IM can provide the same dose used in sublingual administration, or a higher dose that creates a more dissociative experience

The choice of dose and route of administration also depends on multiple factors, including client preference, therapeutic goals, prior exposure to ketamine and other psychedelics, body height and weight, and sensitivity. Those without prior experiences are advised to begin with lower doses to reduce anxiety and build familiarity with ketamine’s effects.

The Ketamine Experience

The ketamine experience is characterized by the relaxation of ordinary concerns and usual mindset, all while maintaining conscious awareness. This tends to lead to a disruption of negative feelings and preoccupations. Some ketamine providers feel that this interruption--and the exploration of other possible states of consciousness- -can lead to significant shifts in overall well-being. 

At lower doses, you will most likely experience anxiolytic, antidepressant, and mild psychoactive effects. You might experience increased sensitivity to light and sound, as well as an altered sense of time. Some people experience empathogenic effects in this dose range. This state may also enhance participation in psychotherapy, as defenses are relaxed, yet communication with others is still possible. 

Higher doses are more likely to produce psychedelic, dissociative states that are largely internal journeys away from the external world. Body sensations are greatly diminished. Such journeys may provide a more robust treatment effect, often assisting in the resolution of existential concerns, accelerating psychological growth, and promoting a positive change in outlook. 

Sensory effects of ketamine may include distorted visualization of colors, feeling suspended in space or floating, experiencing out-of-body sensations, vivid  dreaming, and changes in visual, tactile and auditory processing. Synesthesia (a mingling of the senses) may occur. Familiar music may not be recognizable. These effects typically start 5 to 10 minutes after ketamine dosing. The peak effects typically last 20 to 30 minutes, and then slowly diminish for the next hour. Some alterations in sensory perception, speech, and motor ability may continue for approximately 5 hours. 

Two to three hours after ketamine administration, clients can return home with another driver. Driving an automobile or engaging in hazardous activities should not be undertaken on the day of the administration, and not until all effects have stopped. 

Why Ketamine Assisted Psychotherapy (KAP)? 

The administration of ketamine may be most effective when paired with  psychotherapy. We offer a psychotherapy program that will prepare you for your ketamine sessions, encourage you to explore your mind while within the ketamine space, and assist you in integrating your experiences afterwards. 

This program emphasizes the potential for change, and such change is best facilitated within a structured, supportive psychotherapeutic environment with providers who are aware of your issues, hopes, desires, and struggles. 

Ketamine has the potential to create a non-ordinary state of consciousness, facilitating a profound transpersonal or mystical peak experience. These sorts of peak experiences have been shown to expand one’s sense of self and understanding of existence, and may enable you to access your own healing wisdom. Your clinicians serve as guides and assist in processing the experience and its impact on your everyday life. 

Many have found it beneficial to set an intention for the experience. Intentions should be personal and focused, which could include alterations in habits (such as  the use of alcohol or cannabis, exercising, etc.), shifts in self-defeating patterns of thought or social interactions, or exploration of spiritual/existential realms. Our team will work with you to help formulate your goals, and will also encourage you to hold those lightly, as resistance or attempts to control the experience can produce anxiety. 

Your experience will be unique to you, and each of your sessions will be different. All such journeys are adventures that cannot be programmed. They evolve from your own being in relation to this medicine, and it is best to relax into the path that unfolds. Many enjoy the journey, while others do not. Everyone comes through it, and often with greater insight into themselves and their lives. Our therapy program is designed to assist you in integrating these insights into your daily functioning. 

As a byproduct of your experience, you may feel improvement in your emotional  state and reduction in symptoms such as depression, anxiety, and post-traumatic manifestations. You may notice that you are a bit different after a ketamine experience, and that difference may feel liberating, allowing for new perspectives and behavior. 

These shifts may happen during treatment, in the aftermath, and/or in the days and weeks that follow. Some experiences may be temporarily disturbing to you, and we will work to help you understand these in context of your healing process. Ultimately, we are working to assist you in changing patterns of mind, mood, and  behavior that cause you difficulty and distress. 

Both psychotherapy and medication (including psychedelic medicines) are effective,  but the combination has been shown to be much more powerful than either on its  own. Many come to us having attempted numerous treatments, and we want to  ensure that you have the best possible outcome for your investment. This is a unique opportunity for growth and change, and so we encourage you to actively engage in the therapeutic process as well as the medication administration. 

Our Treatment Process 

Our treatment team consists of a licensed providers who specializes in psychedelic integration. You will meet with us approximately three times before your first ketamine administration. Typically the first meeting is with one of our providers for an intake. This meeting is followed by 1-2 meetings with a licensed therapist trained in KAP. In some situations, your own psychotherapist may serve on the treatment team. 

As a team, we will plan to assess and discuss if KAP is the right intervention for you  at this time. We will also collaboratively decide on the most optimal arc for your  treatment, including the number and frequency of ketamine and integration  sessions. 

In the first meeting, our team will gather information from you about your current and past symptoms, previous treatment attempts, and relevant life history. We will also review your medical history, including past medical and psychiatric problems, current and recent medications, social history including your current substance use. 

In the second preparatory session, a licensed therapist will work with you to reflect on your goals for treatment and to help you set intentions for your experience. We may also offer and teach breathing exercises  and other mindfulness meditation guidance in this session to address any anxiety  you might have going into the experience. 

If desired, your therapist will work with you to collaboratively create an invocation, a set of emotionally evocative and relevant statements to be read to you as the ketamine is  administered, which is meant to induce a growth-oriented mindset for your journey. 

We provide playlists designed to optimize your benefit from the journey. People often find music helpful, as it grounds them and gives them something familiar to hold onto, and can potentially enhance or direct the experience. 

On the day of your ketamine administration, it is very important that you have nothing to eat for 3 hours prior to your treatment and nothing to drink for 1 hour prior. We encourage you to bring a blanket and small pillow such as a travel pillow for neck support. We will provide you with a blindfold. You may also wish to bring small tokens or pictures related to people or places that have been significant to you in your life. 

We will take some time when you arrive to discuss your current state and remind us  all of your intentions for this work. We will also guide you through some gentle breathing and meditation exercises to help you settle into the room and identify anything that needs releasing prior to starting your session.

For sublingual dosing, we will begin treatment with one lozenge of either 50 or  100mg. It will dissolve slowly, and as the ketamine is being absorbed through the  lining of your mouth, you will be asked not to swallow your saliva for at least 10  minutes. It is safe to swallow ketamine, although it may not be absorbed as well if  you do so, resulting in less bioavailable medicine. 

The first dose will give us a measure of your responsiveness to ketamine, and  enable us to witness the effectiveness of the lozenges and adjust the dose if  needed. Some people experience empathogenic effects in this dose range, and engaging in therapeutic exploration can be quite fruitful. Others  find speaking too difficult and prefer an internal focus even at this lower dose. Your preferences for engagement will be respected. 

After 30 minutes, you may be offered a second dose of either sublingual ketamine or intramuscular ketamine. For intramuscular dosing, we will use a dose that we selected for you based on your height and weight, therapeutic goals, and other factors. The injection is given in the upper arm. You will not have to undress for the injection, although you may have to pull your sleeve up. Given this, it is best to come dressed in a short sleeve shirt with a cardigan over it. 

The onset of the IM experience is generally swift, within a few minutes. You will be  largely internally focused for the first 45 minutes. Depending on the duration of the response to the first injection, a third IM injection may be offered.   

Throughout the ketamine session, your providers will be present for support and to guide you through any recommended relaxation exercises, play soothing music, or read your personalized invocation if desired. During these sessions, you will be  offered an eye mask to facilitate the and enhance the experience, and to help you maintain an internal focus. We recommend that you speak as little as possible while experiencing the active effects of this dose of ketamine, as it may be more beneficial for you to stay with the experience. You will have the opportunity to share once the effect of the medicine subsides. 

We will reconnect with you (and potentially resume supportive psychotherapy) when you return from the most active phase of your journey, and are ready and willing to communicate with the outside world. The moments following an altered state can be exquisitely poignant and powerful in their ability to evoke and reshape how we attach to others, and your therapists regard this opportunity with the  importance it deserves. 

You will be welcomed to share about your experience and discuss any insights or alternative perspectives that you discovered; however, some choose to contemplate their experience quietly and discuss at a later integration session. Whatever decision you make in these moments will be respected. 


Following each of the ketamine administrations, you will need to stay in with us for at least one to two hours. People can vary greatly in terms of how quickly the effects clear, so your departure time might vary. Please arrange for some trusted person to pick you up and take you home. We cannot release you to a taxi, and we ask that you not drive at all on the day of your administration. 

When Will I See Positive Effects, and How Long Will They Last? 

Ketamine treatment can result in a number of benefits, and there are now many studies demonstrating its efficacy; however, it is still a relatively new and experimental psychiatric intervention, and there are no guarantees of its outcome.  It is not FDA approved for the treatment of depression and is generally reserved for patients who have not had benefit from FDA approved medications and psychotherapy.

Ketamine is distinguished from other psychotropic medications by its rapid onset, often producing relief in as soon as a few hours. The literature indicates a 70%  initial response rate to ketamine, as well as a remission rate (return of symptoms)  for people with treatment-resistant depression of 40-50%. 

Durable improvement generally occurs with more than one administration, and is most robust when part of an overall treatment program. It may not permanently relieve your condition. If your symptoms respond to ketamine, you may still elect to be treated with other medications and ongoing psychotherapy to reduce the possibility of relapse. Over time, you may also need additional ketamine booster administrations or other therapies to maintain your remission. Some people will elect to continue with maintenance treatments every 2-4 weeks. 

If you do not respond to ketamine after the first administration, repeated treatment will be offered. If you do not respond after a series of 8 dosings, additional ketamine will not be offered. Studies have shown it is not effective to keep repeating ketamine in those who do not respond to the first doses. The treatment team will discuss with you other available options at that time. This is an effective medicine, and it is even more so when you work with it to create positive changes in your life that can sustain your recovery. 

Medical and Psychiatric Eligibility for KAP 

Before participating, you will be carefully interviewed to determine if you are a good candidate for ketamine treatment. This will include discussing your medical and psychiatric history, review of your medical and psychiatric records. You are required to be under the care of a primary care physician to evaluate your overall health, and in particular your respiratory and cardiovascular status. You are also required to be under the care of a mental health provider who will continue your care after your ketamine treatment. 

Some medical conditions need to be treated before you can safely take ketamine. These conditions include unstable angina (chest pain/heart disease), uncontrolled hyperthyroidism, increased intracranial pressure, evidence of liver disease, or a previously demonstrated allergy to ketamine. 


An EKG may be required for those with a history of arrhythmia or a history of cardiovascular issues. Untreated or uncontrolled hypertension is a contraindication  to ketamine use as the substance causes a rise in blood pressure. This increase is typically comparable to normal increases in blood pressure that occur with heavy exercise. 

Pregnant women and nursing mothers are not eligible because of undetermined potential effects on the fetus or nursing child. 

Those with a history of cystitis or other bladder issues may need to be cleared by urological consultation, due to the rare but potentially significant adverse effect of cystitis. Those with a primary psychotic or dissociative disorder or who are currently in a manic or mixed episode are not eligible for treatment with ketamine. Please consult your treating clinician if you are taking anxiety medications such as benzodiazepines, pregabalin, or gabapentin as they may blunt the antidepressant effects of ketamine. Opiates cannot be taken concurrently with ketamine therapy. 


Potential Risks of Ketamine 

Ketamine has an extensive record of safety and has been used at much higher doses for surgical anesthesia, without respiratory depression. As with any other medication, there are also some potential risks and side effects to be informed of and consider. 

The most common physical side effect is a short-term spike in blood pressure,  pulse, or heart rate, which may be a risk to those with heart disease, and can be misinterpreted as a symptom of anxiety. 

Other possibilities for side effects include dizziness/lightheadedness, sedation,  impaired balance and coordination, slurred speech, mental confusion, excitability, diminished ability to see things that are actually present, diminished ability to hear or to feel objects accurately including one’s own body, headache, anxiety, nausea,  vomiting, and diminished awareness of physical functions such as respiration. These effects are transient and resolve as the active phase of the medication ends (generally within 4 hours). 

Repeated, high dose, chronic use of ketamine has caused urinary tract symptoms and even permanent bladder dysfunction or cystitis in individuals abusing the drug. These adverse effects are much less likely in medically supervised ketamine treatment populations, but might include more frequent, painful, or difficult  urination. Please inform your providers immediately if you notice any of these side effects. 

In terms of psychological risk, ketamine has been shown to worsen certain psychotic symptoms in people who suffer from schizophrenia or other serious  mental disorders. It may also worsen underlying psychological problems in people with severe personality disorders and dissociative disorders. 

Management of Adverse Effects 

It is very important to abstain from eating or drinking in the 3 hours prior to your  treatment so as to avoid nausea or vomiting. Driving an automobile or engaging in hazardous activities should not be undertaken on the day of the administration, and not until all effects have stopped. You will be assessed for safety prior to leaving the office premises, and will be required to arrange for a responsible person to drive you home from your sessions.

One of our providers will check your vital signs before and after the administration, and be available throughout the session to monitor and treat any side effects.

Some people report the psychic experiences as bizarre or frightening, while others describe them as pleasurable, joyful, or fascinating. We have found that even frightening experiences can be of paramount value to your transition to recovery from the suffering that brought you to your KAP work. Our team is trained in providing stability for those experiencing extreme states, and you will receive psychotherapeutic help and ongoing guidance as to how to make the best use of these experiences. 

Potential for Ketamine Abuse and Physical Dependence 

Ketamine belongs to the same group of chemicals as phencyclidine (Sernyl, PCP,  “Angel dust”). This group of chemical compounds is known chemically as  arylcyclohexylamines and are classified as hallucinogens (also known as  psychedelics). Ketamine is a controlled substance and is subject to Schedule III  rules under the Controlled Substance Act of 1970. Medical evidence regarding the  issue of drug abuse and dependence suggests that ketamine’s abuse potential is  equivalent to that of phencyclidine and other hallucinogenic substances. 

Phencyclidine and other hallucinogenic compounds do not meet criteria for chemical  dependence, since they do not cause tolerance and withdrawal symptoms. However, cravings have been reported by individuals with the history of heavy use of psychedelic drugs. In addition, ketamine can have effects on mood (feelings), cognition (thinking), and perception (imagery) that may make some people want to use it repeatedly. Therefore, ketamine should never be used except under the direct supervision of a  licensed physician. We have not had clients become dependent on ketamine. 


Alternative Procedures and Treatments 

Psychotherapy without ketamine is available and can be effective. Major Depression  (MDD), PTSD and Bipolar Disorders are usually treated with antidepressant  medications, tranquilizers, mood stabilizers and psychotherapy. PTSD is often also  treated with Eye Movement Desensitization and Reprocessing (EMDR).  Electroconvulsive therapy (ECT), and the recently introduced Transcranial Magnetic  Stimulation (TMS) are also in use for treatment-resistant-depression. 

Are traditional anti-depressant medications not working for you. Ketamine can provide immediate relief and take away some of this pressures that make day to day life difficult. 


Thank you for taking the time to read this important information! We look forward to hearing from you if you are interested in learning more.

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